Synthetic Biology in Pharmaceutical Industry
Synthetic biology is an interdisciplinary field that leverages principles from biology, engineering, and computer science to design and construct new biological parts, devices, and systems. In the pharmaceutical industry, synthetic biology is revolutionizing drug development, production, and delivery by enabling the creation of complex molecules, optimizing metabolic pathways, and producing high-value compounds more efficiently and sustainably.
Our company specializes in providing high-quality biosynthetic products that play critical roles in synthetic biology applications within the pharmaceutical industry. These products include various amino acids, organic acids, vitamins, and other bioactive compounds that are essential for developing innovative therapeutics, enhancing drug efficacy, and improving metabolic engineering processes.
Synthetic biology tools in various steps of drug discovery (Trosset Jean-Yves and Pablo Carbonell, 2015)
Product Applications
Our products have diverse applications in the pharmaceutical industry, addressing various needs from drug development to production efficiency. Below is an expanded discussion of their applications:
| Products | Applications | Pathways/Technologies |
|---|---|---|
| Succinic acid | Used as a building block for drug synthesis, aids in metabolic pathway optimization, production of antibiotics, and anti-inflammatory agents. | Metabolic engineering, fermentation processes, microbial production systems, gene editing (e.g., CRISPR) |
| β-Alanine | Serves as a precursor for pantothenic acid (vitamin B5) and coenzyme A, essential for cellular metabolism. Enhances muscle endurance and performance, used in sports supplements. | Pathway engineering, enzyme optimization, microbial fermentation, recombinant DNA technology |
| DL-Alanine | Utilized in the synthesis of peptides and proteins. Plays a significant role in metabolic engineering to enhance the production of therapeutic proteins and enzymes. | Protein engineering, recombinant DNA technology, synthetic gene networks, cell-free biosynthesis |
| L-Alanine | Important for protein synthesis and metabolic pathway optimization. Used in producing drugs that support liver function and improve immune responses. | Metabolic pathway optimization, gene circuit design, enzyme catalysis, microbial strain development |
| L-Valine | Essential for protein synthesis and muscle recovery. It is used in metabolic engineering to enhance the production of branched-chain amino acids, which are critical for muscle repair and growth. | Pathway optimization, CRISPR gene editing, microbial strain development, synthetic biology chassis |
| D-Panthenol | A precursor to vitamin B5, used in skin care products, wound healing formulations, and in the synthesis of coenzyme A, which is vital for energy metabolism. | Fermentation processes, metabolic pathway optimization, bio-catalysis, enzyme engineering |
| L-Arginine | Crucial for protein synthesis, boosting immune function, wound healing, and cardiovascular health. | Synthetic gene circuits, metabolic engineering, cell-free biosynthesis, microbial production systems |
| L-Malic Acid | An intermediate in metabolic cycles, used in drug formulation and pH control in pharmaceutical preparations. | Metabolic pathway engineering, synthetic biology chassis, fermentation, gene editing |
| L-Isoleucine | Essential for protein synthesis and muscle repair. Used to enhance the production of essential amino acids. | Pathway optimization, metabolic flux analysis, recombinant microbial systems, synthetic gene networks |
| Inositol | Vital for cell membrane synthesis, signal transduction, and pharmaceutical formulations. | Enzyme engineering, pathway optimization, microbial production systems, synthetic biology chassis |
| Calcium D-Pantothenate | Source of vitamin B5, essential for coenzyme A synthesis, used in skin care and wound healing products. | Metabolic engineering, synthetic gene circuits, fermentation processes, microbial strain development |
| L-Citrulline DL-Malate | Enhances athletic performance and supports cardiovascular health. | Metabolic pathway optimization, enzyme catalysis, synthetic biology chassis, recombinant DNA technology |
| L-Citrulline | Improves nitric oxide production for cardiovascular health and is used in sports supplements. | Pathway optimization, recombinant DNA technology, cell-free biosynthesis, microbial production systems |
| L-Glycine | Functions as a neurotransmitter, supports collagen synthesis, and optimizes metabolic pathways. | Synthetic gene circuits, metabolic engineering, enzyme catalysis, gene editing |
| Compound Amino Acid Powder from Plants | Used in nutritional supplements, therapeutic formulations, and enhancing protein synthesis. | Plant metabolic engineering, pathway optimization, enzyme catalysis, synthetic biology chassis |
| 5-Aminolevulinic Acid | Acts as a precursor for heme synthesis and is used in photodynamic therapy applications. | Metabolic pathway engineering, synthetic biology chassis, microbial fermentation, gene editing |
| L-Proline | Supports collagen synthesis, wound healing, and protein structure stabilization. | Metabolic engineering, synthetic gene circuits, enzyme optimization, microbial production systems |
Case Study
D-Panthenol (DP), an alcohol derivative of vitamin B5 (pantothenic acid), finds extensive use in pharmaceutical and cosmetic formulations due to its enhanced stability. It exhibits moderate irritation but is non-allergenic and non-mutagenic. DP, lacking conjugated bonds and chromophores, does not absorb light in the near-ultraviolet or visible spectrum. However, direct spectrometric methods for DP determination post-chromatographic separation have been reported, albeit with lower sensitivity. Other methods include NMR, electrochemical, GC-FID, and LC-MS assays for DP concentration. Derivatization methods involving DP hydrolysis to produce β-alanol have been introduced to enhance sensitivity, enabling detection limits as low as 10-8 g/mL using fluorescence assays. Yet, these methods often require HPLC separation or cumbersome DP extraction steps for adequate selectivity, as NBD and ninhydrin can react with all α-amine-containing components, not solely 3-amino-1-propanol.
Citric acid (CA), a key carboxylic acid in living organisms, serves as a crucial intermediate in the Krebs cycle of aerobic metabolism. This study presents a novel fluorescence method for DP level determination in solution, utilizing CA as a derivatization agent, eliminating the need for separate hydrolysis steps. This approach establishes the foundational parameters for derivatization, enabling the development of a sensitive, reproducible, and accurate DP determination method. The method's efficacy in characterizing DP concentrations in pharmaceutical formulations and its selectivity were validated. Detailed NMR experiments elucidated the chemical structure of the new fluorophore formed by the DP and CA reaction as 6-oxo-3,4-dihydro-2H,6H-pyrido[2,1-b][1,3]oxazine-8-carboxylic acid (ODPC), confirming its potential for various fluorescence-based DP assays.
Fluorescence Assay for the Determination of d-Panthenol Based on Novel Ring-Fused 2-Pyridone Derivative (Wiktor Kasprzyk, et al., 2020)
FAQs
Below, we've compiled some frequently asked questions and responses about these products. If you don't find the answer you're looking for, feel free to reach out to us.
A: The minimum order quantity (MOQ) varies depending on the specific product. Please contact our sales team for more information on MOQs.
A: β-Alanine is used in pharmaceuticals for its role in muscle endurance and performance. It is also used in formulations aimed at reducing fatigue.
A: Yes, we offer discounts for bulk orders. Please inquire with our sales team about pricing for larger quantities.
A: Orders can be placed directly through our website, or you can contact our sales team for assistance with the ordering process.
A: We accept various payment methods, including credit/debit cards, bank transfers, and PO. Our sales team can provide further details on payment options.
A: It's essential to check the regulations in your region regarding the purchase and import of these products. Our sales team can provide assistance and guidance regarding any regulatory requirements.
A: Yes, we offer technical support and guidance to ensure proper usage and application of our products. Please reach out to our customer support team for assistance.
A: DL-Alanine is a racemic mixture of D- and L-Alanine, while L-Alanine and L-Valine are specific amino acids. They are used as building blocks in various drug formulations and can enhance the stability and bioavailability of active ingredients.
A: D-Panthenol, or pro-vitamin B5, is used for its moisturizing and healing properties. It is commonly included in topical formulations for skin healing and in oral supplements.
A: L-Arginine is used to enhance blood flow and is included in formulations for cardiovascular health, wound healing, and immune support.
Reference
- Kasprzyk W, et al. Fluorescence Assay for the Determination of d-Panthenol Based on Novel Ring-Fused 2-Pyridone Derivative. International Journal of Molecular Sciences. 2020; 21(21):8386.