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L-Valine
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L-Valine

Molecular formula diagram of L-Valine

Other Names
2-amino-3-methylbutanoic acid
Description
L-Valine, the L-enantiomer of valine, serves various roles including as a nutraceutical, micronutrient, and metabolite in humans, algae, Saccharomyces cerevisiae, Escherichia coli, and mice. It belongs to the pyruvate family, proteinogenic amino acids, valine, and L-alpha-amino acids. It acts as the conjugate base and acid of L-valerium and L-valine, respectively, and is the enantiomer of D-valine. Additionally, it exists as a tautomer of the L-valine zwitterion. L-Valine, a branched-chain amino acid, is one of the eight essential amino acids and glycogenic amino acids crucial for normal growth, tissue repair, blood sugar regulation, and energy provision in the body.
Molecular Formula
C5H11NO2
Molar Mass
117.15g/mol
Properties
Rhomboid leaf-shaped or flake crystals, off-white
Density
1.316 g/cm3
Melting Point
298 °C (568 °F; 571 K) (decomposition)
Solubility
Soluble in water, slightly soluble in ethanol

Here are some frequently asked questions about L-Valine and L-Valine intermediates, along with their answers. If you don't find the answer you're looking for, feel free to reach out to us.

A: Yes, L-Valine intermediate exhibits moderate solubility in water, which is advantageous for various synthetic applications.

A: Absolutely, L-Valine intermediate plays a pivotal role in pharmaceutical synthesis, particularly in the production of peptides, amino acid derivatives, and other bioactive compounds.

A: Yes, our L-Valine intermediate is available in bulk quantities and is well-suited for large-scale production, ensuring consistent quality and supply.

A: While L-Valine intermediate is generally safe to handle, it is advisable to adhere to standard laboratory practices and employ appropriate protective measures.

A: Certainly, we offer customization services to tailor L-Valine intermediate according to the unique requirements of our clients, ensuring optimal performance in their applications.

A: Various analytical techniques, including but not limited to HPLC (High-Performance Liquid Chromatography), GC-MS (Gas Chromatography-Mass Spectrometry), and NMR (Nuclear Magnetic Resonance) spectroscopy, are employed to assess the purity of L-Valine intermediate with precision.

A: It is imperative to adhere to relevant regulations and guidelines governing the handling, storage, and transportation of L-Valine intermediate, especially in pharmaceutical and chemical manufacturing, to ensure compliance and safety.

L-Valine intermediates find extensive utility across various industries and applications, including but not limited to:
Pharmaceutical Industry
Serving as a crucial building block in the production of pharmaceuticals, L-Valine intermediate facilitates the synthesis of peptides, amino acid derivatives, and other bioactive compounds.
Polymers
L-Valine intermediate finds application in polymer chemistry, facilitating the synthesis of polymers with tailored properties and functionalities for various industrial and commercial purposes.
Chemical Industry
Its versatility and compatibility make L-Valine intermediate an indispensable component in the synthesis of fine chemicals, enabling the creation of specialty compounds for diverse industrial applications.
Agrochemical Manufacturing
L-Valine intermediate plays a vital role in the synthesis of agrochemicals, contributing to the development of crop protection products and enhancing agricultural productivity.
Peptide Synthesis
As a key constituent in peptide synthesis, L-Valine intermediate enables the construction of peptide chains with precision, supporting research and development efforts in biotechnology and pharmaceuticals.

The following figure illustrates the engineering strategies employed to enhance L-valine production in model organisms, transforming them into efficient microbial cell factories. L-valine is an essential branched chain amino acid that is widely used in industrial application. Most metabolically engineered strains prefer to use first generation feedstock such carbohydrate (glucose) as sole carbon and energy source. The choice of renewable carbon sources is also expanding and possibly, lignocellulosic raw material such as xylose and other carbon source; glycerol can be used for improved L-valine production. Driven by advancements in engineering, it becomes feasible to optimize platform microorganisms such as C. glutamicum, E. coli, and B. subtilis for enhanced performance in terms of titer, productivity, and yield. Through targeted engineering interventions, these microbial cell factories are refined to achieve superior efficiency and scalability, thereby enabling cost-effective and sustainable L-valine production processes.

The ridA mutant strains are compromised in l-alanine utilization (Jeffrey M. Flynn and Diana M. Downs, 2013)