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L-Citrulline
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L-Citrulline

Molecular formula diagram of L-Citrulline

Other Names
(S)-2-Amino-5-ureidopentanoic acid, carbamoylornithine, L-Ornithine, N5-(aminocarbonyl)-Ornithine, α-Amino-δ-ureidovaleric acid
Description
L-citrulline, a non-essential amino acid, is naturally synthesized by the body. It stems predominantly from glutamine, the most abundant amino acid. Within the urea cycle, L-citrulline transforms harmful ammonia into urea, which is then expelled through urine. Additionally, L-citrulline aids in nitric oxide (NO) production, facilitating vasodilation and hormone release, including growth hormone and insulin. Its versatility extends to medicine, food, and healthcare, showcasing promising pharmacological benefits.
Molecular Formula
C6H13N3O3
Molar Mass
175.19g/mol
Properties
White crystal or crystal powder
Melting Point
235.5°C
Solubility
Easily soluble in water, insoluble in methanol, ethanol and ether.

Here are some frequently asked questions about L-Citrulline, including its effects, specific uses, and safety. If you don't find the answer you're looking for, feel free to reach out to us.

A: L-Citrulline Chemical is a pure form of the amino acid L-Citrulline, which is commonly used in various industries for its health-promoting properties.

A: L-Citrulline is the free form of the amino acid citrulline, while citrulline malate is a compound consisting of citrulline and malic acid. L-Citrulline is often preferred for its higher purity and potency.

A: Yes, L-Citrulline Chemical is a popular supplement among athletes and fitness enthusiasts due to its potential benefits in promoting exercise performance and recovery.

A: Our L-Citrulline Chemical is produced through a meticulous manufacturing process that ensures high purity and quality standards.

A: L-Citrulline Chemical has been associated with improved cardiovascular health, exercise performance, muscle recovery, immune function, and sexual health, among other benefits.

A: Yes, L-Citrulline Chemical is a popular ingredient in dietary supplements designed to support various health goals.

A: Yes, L-Citrulline Chemical is known for its potential benefits in skincare formulations, including its ability to support skin health and hydration.

A: Yes, L-Citrulline Chemical is derived from non-animal sources and is suitable for both vegans and vegetarians.

A: L-Citrulline Chemical is generally well-tolerated, and few side effects have been reported. However, some individuals may experience mild gastrointestinal discomfort or allergic reactions.

A: L-Citrulline promotes nitric oxide production, which helps relax blood vessels, improving blood flow and supporting overall cardiovascular function.

A: Yes, L-Citrulline can be synergistically combined with various ingredients to enhance its efficacy and address specific health goals or formulation requirements.

A: L-Citrulline is generally recognized as safe (GRAS) by the FDA when used in accordance with good manufacturing practices (GMP) and other regulatory guidelines.

Our L-Citrulline DL-Malate chemical ingredients find versatile applications across various industries. Here are the main areas where L-Citrulline DL-Malate demonstrates its effectiveness:
Pharmaceutical Industry
L-Citrulline Chemical is utilized in the pharmaceutical industry for its potential cardiovascular benefits and its role in treating certain medical conditions.
Cosmetics Industry
L-Citrulline Chemical is incorporated into skincare and cosmetic formulations for its moisturizing properties and potential benefits in promoting skin health.
Food and Beverage Industry
L-Citrulline Chemical is used in the production of functional foods and beverages, including energy drinks and nutritional bars, to enhance their nutritional value and performance-enhancing properties.
Animal Health
L-Citrulline Chemical is added to animal feed to support healthy growth, immune function, and overall well-being in livestock and companion animals.
Sports Nutrition
L-Citrulline Chemical is often incorporated into pre-workout and intra-workout formulas to enhance endurance, reduce fatigue, and promote optimal muscle function.
Dietary Supplements/Nutraceuticals
L-Citrulline Chemical is commonly used as a key ingredient in dietary supplements to support cardiovascular health, exercise performance, and overall well-being.
Research and Development
L-Citrulline is a subject of ongoing research, exploring its potential applications in various fields, including medicine, nutrition, and biotechnology.

The primary natural reservoir of L-citrulline (CIT), a non-essential amino acid with significant health potential, is found in watermelon. Natural sources of CIT, including citrulline malate and watermelon, exert varying effects on a spectrum of health topics, spanning from cardiovascular disease, diabetes, and erectile dysfunction to cancer and athletic performance. CIT present in watermelon offers a natural dietary alternative to pharmaceutical products. The metabolism of CIT is contingent upon the distribution of enzymes within tissues. The accompanying figure illustrates three metabolic pathways: Arg biosynthesis, the Arg-CIT-nitric oxide cycle, and the urea cycle. Three key enzymes govern these pathways, with two involved in CIT synthesis—nitric oxide synthase (NOS) and OTC—and another participating in mammalian CIT catabolism—argininosuccinate synthase (ASS). ASS catalyzes the conversion of CIT into argininosuccinate, a compound pivotal in both metabolic pathways.

L-Citrulline Metabolism (Encarna Aguayo, et al., 2021)