L-Citrulline DL-Malate 2:1/1:1
- Catalog Number: BC-0015
- CAS Number: 372-75-8
- Price: Online Inquiry
| Ingredients | L-Citrulline, DL-Malate |
| Description | L-Citrulline DL-Malate 2:1/1:1 is a blend of L-citrulline and DL malic acid, either in a 2:1 or 1:1 ratio. This compound is a crucial dietary amino acid involved in maintaining healthy circulation and serving as a key intermediate in the urea cycle. Together with arginine and ornithine, citrulline aids in recycling ammonia and effectively generating nitric oxide. By enhancing nitric oxide production and redirecting excess ammonia, citrulline contributes to reducing muscle fatigue during physical activity. Meanwhile, malic acid supports aerobic metabolism, ensuring that muscles receive adequate energy for sustained exercise. |
| Molecular Formula | C16H32N6O11/C10H19N3O8 |
| Molar Mass | 484.47/309.27g/mol |
| Properties | White crystal or crystal powder |
Here are some frequently asked questions about L-Citrulline DL-Malate 2:1/1:1, including its effects, specific uses, and safety. If you don't find the answer you're looking for, feel free to reach out to us.
A: The recommended dosage may vary depending on the intended use and individual factors.
A: Yes, L-Citrulline DL-Malate is commonly used by athletes and fitness enthusiasts to enhance performance, improve endurance, and support recovery.
A: When used as directed, L-Citrulline DL-Malate is generally considered safe.
A: Yes, L-Citrulline DL-Malate is a popular ingredient in many pre-workout formulations due to its potential benefits in improving exercise performance and reducing fatigue.
A: L-Citrulline DL-Malate is generally well-tolerated, and significant side effects are rare. However, some individuals may experience mild gastrointestinal discomfort or allergic reactions.
A: L-Citrulline DL-Malate has shown potential benefits in supporting cardiovascular health by promoting optimal blood flow and blood pressure regulation.
A: Yes, L-Citrulline DL-Malate is known for its potential benefits in improving skin health, including hydration and reducing the appearance of wrinkles. It is commonly used in various skincare formulations.
A: Yes, L-Citrulline DL-Malate is derived from plant-based sources and is suitable for both vegetariansand vegans.
A: L-Citrulline DL-Malate can be safely combined with many other supplements.
A: Yes, L-Citrulline DL-Malate can be used as a standalone supplement. However, it is also commonly combined with other ingredients to create synergistic formulations tailored to specific needs.
| Pharmaceutical Industry | L-Citrulline DL-Malate is utilized in the pharmaceutical industry for the development of various formulations. It may be included in medications designed to address cardiovascular conditions, support liver function, or improve exercise tolerance in specific patient populations. |
| Food and Beverage Industry |
L-Citrulline DL-Malate is often incorporated into energy drinks to provide an extra boost during physical activity or to combat fatigue. Its ability to improve blood flow, enhance nutrient delivery, and promote energy production makes it a popular choice for formulators looking to create energizing beverages. L-Citrulline DL-Malate also can be added to functional foods such as protein bars, granola bars, and snacks. By incorporating this ingredient, manufacturers can enhance the nutritional profile of their products while also providing potential benefits for exercise performance, muscle recovery, and cardiovascular health. |
| Animal Health | L-Citrulline DL-Malate is also used in the animal nutrition industry as a feed additive. It can be included in animal diets to support exercise performance, muscle growth, and overall health in livestock and companion animals. |
| Dietary Supplements/Nutraceuticals | L-Citrulline DL-Malate is commonly used as a key ingredient in dietary supplements aimed at supporting overall health and well-being. Its ability to enhance nitric oxide production, promote good blood flow, and support detoxification processes makes it a valuable addition to various supplement formulations. |
This case discusses the substance citrulline malate (CM), which is thought to have the potential to enhance nitric oxide (NO) synthesis, thereby improving skeletal muscle function and performance. CM is composed of L-citrulline and malic acid, two ingredients that interact at the intramuscular level and may produce more profound effects. Malic acid is thought to increase ATP production rates and improve ongoing pyruvate and energy production. In addition, CM intake may increase the effects of the malate-aspartate shuttle (MAS), thereby increasing ATP availability. Therefore, supplementation of CM may be a valuable enhancer. One mechanism involves the citrulline component of CM, which may help eliminate ammonia produced during the urea cycle. This is important for the increased ammonia production during high-intensity exercise and its association with muscle fatigue. Citrulline may act through mechanisms that detoxify ammonia, enhancing aerobic utilization of pyruvate and ATP supply to skeletal muscle. Citrulline intake has been reported to reduce ammonia accumulation and increase swimming endurance times. In addition, citrulline supplementation can also reduce post-exercise lactate concentrations and support mechanisms that enhance aerobic utilization. This mechanism has been supported in animal studies (mouse models), but the effect in humans has not been fully established, and further research is needed to confirm the role of these mechanisms in humans. The accompanying figure illustrates the mechanisms associated with citrulline malate supplementation. Bold indicates active ingredients. Left: Increased bioavailability of the malate mechanism, Right: Increased efficiency of the malate aspartate shuttle (MAS). *Indicates evidence is speculative or observed only in mice.
A schematic representation of the mechanisms associated with citrulline malate supplementation (Lewis A. Gough, et al., 2021)