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5-Aminolevulinic acid
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5-Aminolevulinic acid

Molecular formula diagram of 5-Aminolevulinic acid

Other Names
5-ALA, Levulan, NatuALA, Ameluz
Ingredients
5-ALA content 25g/L
Mercury (Hg)≤2mg/kg
Arsenic (Hg)≤15mg/kg
Cadmium (Cd)≤3mg/kg
Lead (Pb)≤50mg/kg
Chromium (Cr)≤150mg/kg
Description
5-Aminolevulinic acid (5-ALA for short) is an amino acid derivative widely present in animal and plant cells and microorganisms. It is an important intermediate substance in the synthesis of azole compounds. It is a functional non-protein amino acid naturally occurring in organisms. It is an essential precursor for the biosynthesis of tetrapyrrole compounds such as heme, chlorophyll, and vitamin B12. It has an important impact on plant photosynthesis and cell energy metabolism.
Molecular Formula
C5H9NO3
Molar Mass
131.131g/mol
Function
Promote chlorophyll synthesis and enhance photosynthesis
Promote fruit coloring
Promote crop growth and increase dry matter accumulation
Improve crop resistance
Properties
White to off-white crystalline powder
Melting Point
118 °C (244 °F)
Solubility
Highly soluble in water, soluble in ethanol and methanol
pH Value
2.5-4.5
Usage Suggestions
In the direction of promoting green leaf growth, spray 5-7g/mu on the leaves, mix with 1 pot (15kg) of water
In the direction of color change and sweetening, spray 6-9g/mu on the leaves, mix with 1 pot (15kg) of water
To nourish roots, promote growth and resist stress, apply 500-1000g/acre.
The amount of compound fertilizer added is 50-100kg/T
The compound addition amount of foliar fertilizer is 100-180kg/T

To ensure that you have all the information you need, we have compiled a list of frequently asked questions about 5-Aminolevulinic acid (ALA). If you can't find the answer you're looking for, please don't hesitate to reach out to us. We're here to assist you.

A: 5-ALA promotes chlorophyll synthesis, enhances photosynthesis, and improves overall plant growth and vitality.

A: 5-ALA increases the production of chlorophyll, which is essential for the photosynthesis process, thereby boosting the plant's ability to convert light energy into chemical energy.

A: Yes, 5-ALA has been shown to improve plant resilience to stress factors such as drought, salinity, and extreme temperatures.

A: 5-ALA can be applied through foliar sprays, soil drenches, or incorporated into fertilizers to ensure effective uptake by plants.

A: Yes, 5-ALA is considered safe and is often used in organic farming practices due to its natural occurrence and beneficial effects on plant health.

A: A wide variety of crops, including vegetables, fruits, grains, and ornamental plants, benefit from 5-ALA application due to its broad-spectrum efficacy.

A: 5-ALA enhances flowering and fruit setting by improving the plant’s metabolic processes and energy production.

A: Yes, 5-ALA is effective in hydroponic systems and can significantly improve plant growth and yield in such environments.

A: 5-ALA is compatible with most agrochemicals, but it is always advisable to conduct a compatibility test before mixing with other products.

5-Aminolevulinic acid is widely used in agriculture, medicine and cosmetics, especially in plant growth regulation, photodynamic therapy and skin care products. Here are the main areas where 5-Aminolevulinic acid demonstrates its effectiveness:
Medical
In the medical field, 5-ALA is widely used in photodynamic therapy (PDT) for the treatment of certain cancers. It is also employed in photodiagnosis to help image and detect cancers more accurately. 5-ALA’s ability to selectively accumulate in cancer cells makes it a powerful tool for targeted therapies.
Cosmetics
5-ALA is incorporated into skincare products due to its anti-aging and skin rejuvenation properties. It helps improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful and radiant complexion. Skincare products containing 5-ALA are highly sought after for their effectiveness in maintaining healthy skin.
Agriculture
5-Aminolevulinic Acid significantly enhances plant growth, promotes chlorophyll synthesis, and boosts photosynthesis efficiency. It helps improve crop yields and quality, making it a valuable tool for farmers looking to maximize their productivity. Additionally, 5-ALA improves plant resilience to environmental stressors such as drought, salinity, and extreme temperatures, ensuring healthier and more robust crops.
Research and Development
In scientific research, 5-ALA is used as a biochemical reagent in studies related to heme biosynthesis and chlorophyll production. Its role as a precursor in these pathways makes it a valuable compound for researchers investigating cellular processes and metabolic functions.
Horticulture
In horticulture, 5-ALA is used to improve the health and aesthetic quality of ornamental plants. It enhances flowering, coloration, and overall vitality, making plants more attractive and marketable. Whether for commercial flower production or home gardening, 5-ALA helps achieve superior plant performance.
Environmental Science
5-ALA is utilized in bioremediation efforts to enhance the degradation of pollutants by microorganisms. This application is crucial for environmental clean-up projects, where 5-ALA aids in breaking down harmful substances, thereby contributing to the restoration of polluted environments.

5-Aminolevulinic acid (ALA) was found to improve tolerance to various stresses and is a promising chemical molecule for agricultural applications. ALA is found in a wide variety of organisms, including bacteria, algae, plants and animals, and is a universal precursor for the synthesis of all tetrapyrroles (chlorophyll, heme, heme, vitamin B12 and the phytochrome bile protein). Below sketch shows the biosynthetic pathway of ALA and the use of ALA as a substrate for the synthesis of chlorophyll and heme in plants. ALA is created in stroma of chloroplast. The main biosynthetic pathway of ALA is the Beal pathway, which starts from glutamic acid. L-Glutamate is ligated to tRNAGlu, which is catalyzed by glutamyl–tRNA synthetase (GluTS) to form L-glutamy–tRNA. Then, Glu-tRNA is converted to L-glutamic acid 1-semialdehyde (GSA), a reaction catalyzed by the key rate-limiting enzyme glutamyl–tRNA reductase (GluTR). GSA then undergoes an isomerization reaction catalyzed by glutamate-1-semialdehyde aminotransferase (GSAT) to form ALA. Two molecules of ALA are catalyzed by ALA dehydratase (ALAD) and agglomerate to form a pyrrole ring called porphobilinogen (PBG). Then, after a six-step enzymatic reaction, four molecules of PBG polymerize to form a porphyrin structure, eventually forming (PpIX). PpIX combines with different enzymes and substrates to yield different products; PpIX chelates Fe2+ with Ferrochelatase (FECH) to produce heme, and Mg2+ with Mg-chelatase (MCH), and then undergoes a series of catalytic reactions to produce chlorophyll.

 A sketch shows the biosynthetic pathway of ALA and the use of ALA as a substrate for the synthesis of chlorophyll and heme in plants (Shuya Tan, et al., 2022)