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L-Alanine
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L-Alanine

Molecular formula diagram of L-alanine

Other Names
2-aminopropionic acid; L-ALA
Description
L-alanine is one of more than 20 amino acids that make up human proteins. It is a neutral non-essential amino acid containing carboxyl and amino groups in the molecule. It is also the amino acid with the highest content in human blood. L-alanine can participate in sugar and acid metabolism, enhance immunity, and provide energy for muscle tissue, brain and central nervous system. L-alanine is the left-rotating isomer of alanine, corresponding to D-alanine (dextral isomer).
Molecular Formula
C3H7NO2
Molar Mass
89.05g/mol
Properties
White odorless crystalline powder
Density
1.2±0.1 g/cm3
Boiling Point
212.9±23.0 °C at 760 mmHg
Melting Point
314.5 °C (dec.)(lit.)
Flash Point
82.6±22.6 °C

Here are some frequently asked questions about L-Alanine and L-Alanine intermediates, along with their answers. If you don't find the answer you're looking for, feel free to reach out to us.

A: L-Alanine is a non-essential amino acid, which means that our bodies can naturally produce it. It's not just a simple building block of proteins, but it also plays a crucial role in important physiological functions such as the metabolism of glucose, which provides energy to our cells, and the detoxification process that helps cleanse our bodies from harmful substances.

A: L-Alanine intermediates are compounds that are derived from L-Alanine. They are known for their chemical stability, which makes them resistant to changes in their environment, and their versatility in various chemical reactions, which allows them to be used in a wide array of applications.

A: L-Alanine intermediates have a broad range of uses. They are widely used in the production of pharmaceuticals, where they can be used to create medications. They are also used in making chemical products, and in some cases, they can even be used in food products.

A: Yes, with the right precautions and safety measures in place, L-Alanine intermediates can be handled safely. However, it's always important to follow the recommended handling guidelines to ensure safety.

A: Absolutely, L-Alanine intermediates can be stored under proper conditions for future use. These conditions will depend on the specific type of intermediate, but generally involve a cool, dry, and dark environment.

A: The production of L-Alanine intermediates typically takes place in a laboratory setting. It involves a series of chemical reactions that use L-Alanine as a starting material.

A: Generally speaking, L-Alanine intermediates are safe to use when they are handled correctly and used as directed by a professional. However, as with any substance, it's always important to use them responsibly and to be aware of any potential reactions or interactions.

A: Yes, some L-Alanine intermediates can indeed be used in food products. However, the specific use would depend on the type of intermediate and must always adhere to the regulatory guidelines in place for food safety.

A: The shelf life of L-Alanine intermediates can vary widely depending on the specific type of intermediate and the conditions in which it’s stored. Certain factors such as temperature, humidity, and exposure to light can affect their longevity.

A: Yes, our company specializes in the production of a range of L-Alanine intermediates and offers them for purchase. We are committed to providing high-quality products that meet the needs of our customers.

L-Alanine intermediates play a key role across a multitude of industries, and their applications are varied and expansive. Here are some of their prime applications in more detail:
Pharmaceutical Industry
L-Alanine intermediates are indispensable in the domain of pharmaceutical manufacturing. They are used in the synthesis of an array of drugs. Their unique properties make them a fundamental component in the development of effective medications. This involves the creation of novel drugs, the enhancement of existing pharmaceutical products, and the formulation of efficient drug delivery systems.
Bio-plastics Manufacturing
The chemical industry extensively exploits the stability and versatility of L-Alanine intermediates. They take center stage in a broad array of chemical reactions. Their robust nature lets them withstand a variety of conditions, and their reactivity allows them to participate in unique chemical transformations. This makes them an essential element in numerous chemical manufacturing processes, such as the synthesis of polymers, the formulation of resins, and the creation of various other chemical compounds.
Cosmetics
Certain L-Alanine intermediates are used in the cosmetics industry. They can be found in products like skin creams and lotions, where they can help improve texture and stability.
Food and Beverage Industry
Certain L-Alanine intermediates are also employed as additives in food products. They serve to augment the nutritional value of food items and enhance their sensory attributes. This can include improving the taste and appearance of food products, boosting their nutritional profile, and even extending their shelf life. L-Alanine intermediates can be used in the creation of food colorings, flavor enhancers, and preservatives, among other things.
Agriculture
L-Alanine intermediates can be used in the manufacture of certain types of fertilizers and pesticides. Their chemical properties can help enhance the nutritional content of soil and protect crops from pests.
Biotechnology
In the field of biotechnology, L-Alanine intermediates are used in various research and development processes, including the production of biofuels and other bio-products.
Crop Cultivation
L-Alanine has certain stress resistance in plants and can help plants cope with adverse effects of various external environments. In the face of drought, high temperature, salinity and other adverse conditions, an appropriate supply of L-Alanine can enhance the plant's ability to adapt to stress and improve the plant's stress resistance and survival rate.
Soil Treatment
L-Alanine also contributes to the overall health and fertility of the soil. As a natural source of organic nitrogen, our L-Alanine products help replenish depleted soils, stimulate microbial activity, and improve soil structure, creating a thriving environment for your plants to flourish.

Bacterial alanine racemases are enzymes containing pyridoxal 5'-phosphate (PLP) that facilitate the conversion of l-alanine to d-alanine, and vice versa, as depicted in the figure below. In organisms like Escherichia coli and Salmonella enterica, both biosynthetic (Alr) and catabolic (DadX) alanine racemases are encoded in the genome. While these proteins share homology, their in vivo functions differ due to distinct regulation of expression. Alr is crucial for synthesizing d-alanine, essential for peptidoglycan formation in the cell wall, and is expressed constitutively at a low level. Below figure illustrates the catalytic mechanism of alanine racemase and the pathway for l-alanine utilization. Both Alr and DadX facilitate the reversible racemization between d- and l-alanine. I, PLP cofactor is bound to the enzyme via an internal aldimine bond; II, l-alanine attacks the aldimine linkage, displacing the lysine, and forms an external aldimine; III, the abstraction of the α-proton results in a quinonoid intermediate; and IV, the addition of the α-proton on the opposite side of the molecule results in the formation of d-alanine external aldimine which can be released to obtain structure I again. In l-alanine catabolism, l-alanine is racemized to d-alanine via the catabolic alanine racemase, DadX. d-Alanine is then oxidized via d-amino acid dehydrogenase, releasing ammonia and pyruvate.

The ridA mutant strains are compromised in l-alanine utilization (Jeffrey M. Flynn and Diana M. Downs, 2013)