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Calcium D-Pantothenate
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Calcium D-Pantothenate

Molecular formula diagram of Calcium D-Pantothenate

Other Names
D-Pantothenic acid hemicalcium salt, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B5
Description
Calcium pantothenate, the calcium form of vitamin B5, is abundant in both plant and animal tissues and possesses antioxidant properties. Functioning as a crucial component of coenzyme A, it plays a vital role in the metabolism of carbohydrates, fats, and proteins, essential for maintaining normal physiological functions in both humans and animals. Additionally, it is a key component of the vitamin B complex, serving as a growth factor vital for various metabolic processes, including the synthesis of cholesterol, lipids, neurotransmitters, steroid hormones, and hemoglobin.
Molecular Formula
C18H32CaN2O10
Molar Mass
476.5g/mol
Properties
White powder

Here are some frequently asked questions about Calcium D-Pantothenate, including its effects, specific uses, and safety. If you don't find the answer you're looking for, feel free to reach out to us.

A: Calcium D-Pantothenate offers a myriad of benefits, including supporting energy metabolism, promoting healthy skin and hair, and aiding in hormone synthesis.

A: Yes, Calcium D-Pantothenate is generally recognized as safe (GRAS) by regulatory authorities worldwide when used in accordance with recommended guidelines.

A: Calcium D-Pantothenate finds applications across diverse industries, including pharmaceuticals, food and beverage, cosmetics, and animal nutrition.

A: Absolutely! Calcium D-Pantothenate is a common ingredient in dietary supplements, providing essential Vitamin B5 to support overall health and wellness.

A: The recommended dosage varies depending on factors such as age, health status, and specific formulations.

A: Yes, Calcium D-Pantothenate can be derived from both synthetic and natural sources, making it suitable for vegan and vegetarian products.

A: Certainly! Calcium D-Pantothenate is often included in skincare and hair care formulations for its moisturizing and nourishing properties.

A: Calcium D-Pantothenate is generally compatible with a wide range of ingredients commonly used in formulations, minimizing the risk of adverse interactions.

A: Yes, Calcium D-Pantothenate exhibits excellent stability in various formulations, including those with different pH levels and environmental conditions.

A: Yes, Calcium D-Pantothenate is known to support healthy hair growth and may be included in formulations aimed at enhancing hair health and appearance.

Calcium D-Pantothenate, with its remarkable properties and versatile nature, finds extensive application across various industries. Here are some of the main areas where this exceptional ingredient is utilized:
Pharmaceutical Industry
Calcium D-Pantothenate plays a vital role in the pharmaceutical industry. It is utilized in the formulation of medications, vitamins, and nutraceuticals. As an essential component of coenzyme A (CoA), it is involved in numerous metabolic pathways, supporting energy production, and overall cellular health. Calcium D-Pantothenate is often included in multivitamin formulations and supplements targeting specific health concerns.
Industrial Chemical Production
Beyond its uses in the aforementioned industries, Calcium D-Pantothenate has relevance in industrial settings. It serves as a valuable chemical compound for various synthesis and research applications. Its unique properties and role as a precursor in CoA synthesis make it a sought-after ingredient for chemical processes and scientific investigations.
Cosmetics
The skincare and hair care industries benefit greatly from the properties of Calcium D-Pantothenate. Due to its excellent moisturizing and soothing properties, it is commonly incorporated into skincare products, such as lotions, creams, and serums. It helps improve the skin's barrier function, promotes hydration, and aids in the repair of damaged skin. In hair care formulations, Calcium D-Pantothenate helps strengthen and nourish hair, leaving it healthier and more manageable.
Food and Beverage Industry
In the food and beverage industry, Calcium D-Pantothenate is widely used for fortifying a range of products. It is incorporated into fortified foods, such as breakfast cereals, energy bars, and nutritional drinks, to enhance their nutritional value. Additionally, it is a common ingredient in dietary supplements, providing individuals with a convenient way to meet their daily vitamin B5 requirements.
Animal Health
Calcium D-Pantothenate plays a critical role in animal nutrition. Livestock, poultry, and pets require adequate amounts of vitamin B5 for optimal growth, energy utilization, and overall health. Calcium D-Pantothenate is added to animal feed formulations to meet these nutritional requirements. It supports various physiological functions, including nutrient metabolism, hormone synthesis, and immune system function, ensuring the well-being of animals.
Agriculture
Calcium D-Pantothenate also finds application in the agricultural sector. It is utilized as a plant nutrition supplement and growth enhancer. When applied to plants, it aids in their overall development, including root growth, nutrient absorption, and stress tolerance. By incorporating Calcium D-Pantothenate into agricultural practices, farmers can enhance crop productivity and promote healthier plants.

Pantothenic acid, commonly referred to as vitamin B5, serves as a vital nutrient within various metabolic pathways. Notably, it demonstrates a distinct inclination towards interacting with Ca(II) ions, which are plentiful in extracellular environments and play a role as secondary mediators in numerous biological processes. Through electrospray ionization, the gas-phase forms of pantothenic acid—including the unadorned deprotonated form ([panto-H]−), its complex with Ca(II) ions ([Ca(panto-H)]+), and the singly charged micro-hydrated calcium pantothenate adduct ([Ca(panto-H)(H2O)]+)—have been acquired and scrutinized via mass spectrometry and IR multiple photon dissociation spectroscopy within the fingerprint spectral range. Quantum chemical calculations at the B3LYP(-D3) and MP2 levels of theory were conducted to model geometries, thermochemical data, and linear absorption spectra of low-lying isomers, facilitating the attribution of experimental absorptions to specific structural motifs. In the gas phase, pantothenate was identified to exist predominantly as a single isomeric form, featuring deprotonation on the carboxylic moiety. Conversely, the free and monohydrated calcium complexes of deprotonated pantothenic acid each exhibit at least two isomers within the gas-phase population, sharing the deprotonation of pantothenate on the carboxylic group and either a fourfold or fivefold coordination with calcium. This phenomenon underscores the pronounced affinity of pantothenate for the metal.

Molecular Properties of Bare and Microhydrated Vitamin B5–Calcium Complexes (Davide Corinti, et al., 2021)