Synthetic Biology in Cosmetics Industry
Synthetic biology is a rapidly advancing field that combines principles from biology, engineering, and technology to design, create, and modify new biological systems, often at the molecular or genetic level. In the cosmetics industry, synthetic biology is revolutionizing the creation and production of ingredients, leading to sustainable, high-performance products that enhance beauty and personal care.
We offer a range of products derived from synthetic biology that are designed to meet the highest standards of the cosmetics industry. These innovative solutions are paving the way for the development of cutting-edge, effective ingredients and products that cater to diverse beauty needs while promoting sustainability and ethical practices.
Results of an overview of original publications about polymers applied in cosmetic formulations (Alves, T.F.R., et al., 2020)
Product Applications
The table below demonstrates how synthetic biology is transforming the cosmetics industry by providing sustainable, efficient and effective solutions to modern beauty needs. By leveraging advanced biotechnology, we can create high-quality ingredients that improve cosmetic performance and safety while promoting environmental sustainability. Explore our range of synthetic biology-derived cosmetic ingredients and see how they can enhance your beauty formulas.
| Products | Applications | Pathways/Technologies |
|---|---|---|
| 1,3-Propanediol | Used as a skin conditioning agent and anti-aging ingredient. It helps to improve skin texture and elasticity, reducing the appearance of fine lines and wrinkles. | Bio-based production through microbial fermentation using engineered strains of bacteria like Clostridium or E. coli. |
| Succinic acid | Acts as a humectant and skin hydration agent. It helps to attract and retain moisture in the skin, making it smooth and supple. | Produced through fermentation using engineered microbes that convert renewable feedstocks into succinic acid. |
| β-Alanine | Serves as an anti-aging and skin conditioning agent. It helps to improve skin elasticity and reduce the signs of aging. | Produced via fermentation using engineered bacteria that can convert glucose into β-Alanine through specific metabolic pathways. |
| D-Panthenol | Commonly used as a moisturizer and conditioning agent for skin and hair. It enhances hydration, reduces inflammation, and improves the appearance of skin and hair. | Synthesized through the fermentation of D-pantothenic acid using genetically engineered microorganisms. |
| α-Arbutin | Used for skin brightening and reducing hyperpigmentation. It inhibits melanin production, leading to a more even skin tone. | Enzymatic synthesis using engineered yeast or bacteria that can convert plant-derived compounds into α-Arbutin. |
| β-Arbutin | Similar to α-Arbutin, it is used for skin brightening and reducing dark spots and pigmentation. | Produced through enzymatic synthesis using genetically modified microbes that facilitate the conversion of precursor molecules. |
| L-Arginine | Provides skin hydration and anti-aging benefits. It helps to improve skin barrier function and elasticity. | Produced through fermentation using genetically modified bacteria that can efficiently synthesize L-Arginine from simple sugars. |
| L-Malic acid | Acts as an exfoliant and skin conditioning agent. It helps to remove dead skin cells and improve skin texture. | Fermented using engineered microbes that convert renewable feedstocks into L-Malic acid through optimized metabolic pathways. |
| Inositol | Used as a moisturizer and anti-aging ingredient. It helps to improve skin hydration, reduce inflammation, and enhance hair conditioning. | Produced through fermentation using engineered yeast that can efficiently synthesize inositol from glucose. |
| Calcium D-Pantothenate | Functions as a moisturizer, hair conditioning agent, and wound healing ingredient. It supports skin barrier function and improves hair health. | Fermented using genetically modified bacteria designed to produce high levels of this vitamin. |
| 5-Aminolevulinic acid | Used in photodynamic therapy for acne treatment and as an anti-aging ingredient. It helps to rejuvenate skin and treat various skin conditions. | Produced through fermentation using engineered microbial strains that can convert simple sugars into 5-Aminolevulinic acid. |
| L-Proline | Provides anti-aging and skin repair benefits. It helps to improve skin elasticity and promote collagen synthesis. | Produced through fermentation using genetically modified bacteria that are optimized to produce L-Proline from renewable resources. |
Case Study
Many natural extracts used in cosmetics are available in high-boiling-point carrier solvents like propylene glycol, propanediol, and glycerin. Chemical profiling of these extracts is beneficial for the cosmetic industry, as it speeds up product development. This case study presents a new rapid characterization workflow for metabolites in extracts diluted in propylene glycol and propanediol, building on previous work with glycerin-containing extracts. The method involves centrifugal partition chromatography (CPC) followed by 13C nuclear magnetic resonance (NMR) analysis and data processing, with evaporation under reduced pressure as a preliminary step for highly diluted extracts. A dried hydro-ethanolic extract of Leontopodium alpinum Cass. was prepared and validated using three solutions (5% wt. dry extract) in different carrier solvents: propylene glycol/water, 1,3-propanediol/water, and glycerin/water (all 1:1). The workflow was applied to these extracts, identifying 26 metabolites, including flavonoids, hydroxycinnamic acids, sugars, and organic acids.
The proposed workflow includes CPC fractionation for solvent suppression, with optional evaporation for highly diluted extracts. Two CPC methods are used based on the carrier solvent: isocratic elution for glycerin (EtOAc/CH3CN/water 3:3:4) and gradient elution for propylene glycol or propanediol (MtBE/n-BuOH/water 45:5:50 to 5:45:50). This step yields 10 to 20 simplified fractions. Next, 13C NMR analysis is performed on each fraction. In conclusion, this optimized workflow using CPC and 13C NMR allows rapid and efficient metabolite identification in natural extracts diluted in various carrier solvents, enhancing the cosmetic industry's chemical profiling capabilities.
Workflow for the dereplication of extracts diluted in propylene glycol, propanediol and glycerin (Marine Canton, et al., 2021)
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References
- Alves TFR, et al. Applications of Natural, Semi-Synthetic, and Synthetic Polymers in Cosmetic Formulations. Cosmetics. 2020; 7(4):75.
- Canton M, et al. Dereplication of Natural Extracts Diluted in Propylene Glycol, 1,3-Propanediol and Glycerin. Comparison of Leontopodium alpinum Cass. (Edelweiss) Extracts as a Case Study. Cosmetics. 2021; 8(1):10.