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α-Arbutin

Molecular formula diagram of α-Arbutin

Other Names alpha-Arbutin, Hydroquinone-O-α-d-glucopyranoside, 4-Hydroxyphenyl α-d-gluco-hexopyranoside
Description α-Arbutin is one of the safest and most effective whitening raw materials currently popular. We use sucrose and hydroquinone to react and synthesize it through microbial catalysis. As a glycosylated hydroquinone, alpha-arbutin serves as the anomer of natural arbutin. Embraced by both the cosmetic and pharmaceutical sectors, alpha-arbutin is renowned for its skin-lightening capabilities, its efficacy in addressing hyperpigmentation, and its status as a safer alternative to hydroquinone.
Molecular Formula C12H16O7
Molar Mass 272.25g/mol
Properties White or off-white crystal or powder
Boiling Point 285 °C (545 °F; 558 K) at 102.17 kPa
Melting Point 201 °C (394 °F; 474 K)
Solubility in Water 151 g/L

Here are some frequently asked questions about α-Arbutin, including its effects, specific uses, and safety. If you don't find the answer you're looking for, feel free to reach out to us.

A: Yes, α-Arbutin is considered safe for all skin types, including sensitive skin, as it is a naturally derived ingredient with low irritancy potential.

A: Results may vary depending on individual skin types and conditions, but many users report noticeable improvements in skin tone and brightness within a few weeks of consistent use.

A: Absolutely! α-Arbutin is compatible with a wide range of skincare ingredients and can be seamlessly incorporated into your existing skincare routine for enhanced brightening effects.

A: When used as directed, α-Arbutin is generally well-tolerated by most individuals. However, as with any skincare product, some people may experience mild irritation or sensitivity.

A: Yes, α-Arbutin can be beneficial for individuals with acne-prone skin, as it can help fade post-inflammatory hyperpigmentation (PIH) caused by acne lesions, resulting in a more even complexion.

A: Yes, α-Arbutin can help lighten dark circles and brighten the under-eye area with regular use, resulting in a more refreshed and youthful appearance.

A: Absolutely! α-Arbutin can be applied to any area of the body experiencing hyperpigmentation or uneven skin tone, such as the neck, chest, hands, and arms, for targeted treatment.

A: Compared to other skin-brightening ingredients, such as hydroquinone or kojic acid, α-Arbutin is prized for its stability, efficacy, and gentle yet potent brightening effects, making it a popular choice for individuals seeking a safe and effective solution for achieving radiant, even-toned skin.

α-Arbutin is a popular ingredient in skincare and cosmetic formulations due to its skin-brightening and hyperpigmentation-reducing properties. It is widely used in various products to promote a lighter, more even complexion. Here's a table outlining some of the main applications of α-Arbutin:
Cosmetics It is used in the formulation of various cosmetics, including creams, lotions, serums, and masks, to enhance the overall complexion and address pigmentation issues.
Skin Lightening α-Arbutin is widely used in skincare products for its ability to inhibit melanin production, resulting in a lighter and more even skin tone.
Hyperpigmentation Treatment It is effective in reducing the appearance of hyperpigmentation, including age spots, dark spots, and melasma.
Sunscreen Formulations α-Arbutin can be incorporated into sunscreen formulations to provide added protection against UV-induced skin damage.
Anti-Aging Products Due to its skin-brightening properties, α-Arbutin is often included in anti-aging products to promote a youthful and radiant complexion.

Despite widespread efforts through regulations and public health campaigns, the use of skin lightening agents remains prevalent globally. This is partly due to the deceptive marketing of harmful skin bleaching agents as ready-made skin lighteners, toners, or dark spot removal creams. However, there is a safer alternative in the form of Alpha-Arbutin. It serves as a substitute for hydroquinone and other damaging skin lightening agents. Alpha-Arbutin works by inhibiting the activity of tyrosinase and impeding melanosome maturation. It has gained significant popularity worldwide and is extensively utilized in treating various hyperpigmentation disorders. The cosmetic and pharmaceutical industries highly value Alpha-Arbutin, contributing to its considerable market demand. The image below illustrates the mechanism of action of Alpha-Arbutin in skin whitening.

 Mechanism of action of α-Arbutin for skin lightening (Nikhil Chandorkar, et al., 2021)