Here are some frequently asked questions about β-arbutin, including its effects, specific uses, and safety. If you don't find the answer you're looking for, feel free to reach out to us.
A: Yes, beta-arbutin is generally considered safe for all skin types, including sensitive skin.
A: Yes, beta-arbutin is compatible with most skin care ingredients.
A: No, beta-arbutin does not increase sensitivity to sunlight like some other whitening agents.
A: Beta-arbutin may help fade hyperpigmentation caused by acne scars.
A: Yes, the beta-arbutin ingredient can be used on sensitive areas, but avoid applying it to broken or irritated skin.
A: Beta-arbutin is generally well tolerated, but some people may experience mild irritation or allergic reactions.
A: Yes, beta-arbutin can be used with chemical exfoliants, but it must be done gradually to prevent over-exfoliation and irritation.
Arbutin, an active ingredient widely utilized in the cosmetic industry, has garnered significant attention for its remarkable skin whitening properties. However, recent research has shed light on an additional facet of arbutin—the potential anticarcinogenic effects it can offer.
The case examined the impact of β-arbutin on MCF-7 cells and identified the key mediators of its anticarcinogenic effects. It was observed that when MCF-7 cells were exposed to the LD50 dose of β-arbutin, inflammation and genotoxicity were stimulated. Surprisingly, there were no significant changes in oxidative stress, endoplasmic reticulum stress, or proliferation levels. These findings led to a remarkable discovery: β-arbutin triggers the activation of p53 and cas3 pathways through inflammation and genotoxicity, ultimately inducing apoptosis in the cells. This groundbreaking revelation paves the way for the potential use of β-arbutin as an anticancer agent. The determination of these mechanisms not only highlights the anticancer potential of β-arbutin but also opens up new perspectives and possibilities for innovative treatment approaches.
Mechanisms that mediate the anticarcinogenic effects of β-arbutin administration to MCF-7 cells (Omer Hazman, et al., 2021)