β-Arbutin
- Catalog Number: BC-0009
- CAS Number: 497-76-7
- Price: Online Inquiry
| Other Names | 4-Hydroxyphenyl-β-D-glucopyranoside, Beta Arbutin |
| Description | β-Arbutin, derived from bearberry leaves, is a widely used whitening ingredient known for its ability to regulate the production of melanin pigments responsible for discoloration and freckles. Discoloration and freckles occur when reactive oxygen species are generated in the skin due to factors like UV exposure, stress, and environmental pollution. These factors activate the enzyme tyrosinase, which leads to the conversion of tyrosine in melanocytes (pigment cells) into melanin pigments. β-Arbutin works directly on tyrosinase in melanocytes to reduce the production of melanin pigments, thereby demonstrating its whitening effects. It is a popular choice in skincare products aiming to achieve a more even and radiant complexion. |
| Molecular Formula | C12H16O7 |
| Molar Mass | 272.25g/mol |
| Properties | White or off-white crystals |
| Melting Point | 198–202°C |
| Solubility | Soluble, 13%/room temperature |
Here are some frequently asked questions about β-arbutin, including its effects, specific uses, and safety. If you don't find the answer you're looking for, feel free to reach out to us.
A: Yes, beta-arbutin is generally considered safe for all skin types, including sensitive skin.
A: Yes, beta-arbutin is compatible with most skin care ingredients.
A: No, beta-arbutin does not increase sensitivity to sunlight like some other whitening agents.
A: Beta-arbutin may help fade hyperpigmentation caused by acne scars.
A: Yes, the beta-arbutin ingredient can be used on sensitive areas, but avoid applying it to broken or irritated skin.
A: Beta-arbutin is generally well tolerated, but some people may experience mild irritation or allergic reactions.
A: Yes, beta-arbutin can be used with chemical exfoliants, but it must be done gradually to prevent over-exfoliation and irritation.
| Pharmaceutical Industry | Beta-arbutin has topical therapeutic potential to improve skin-related diseases and conditions for use in dermatological formulations |
| Food and Beverage Industry | Beta-alanine can be used to prepare various functional foods, such as high-protein foods, nutritionally balanced energy bars and immune-boosting nutritional drinks, to provide consumers with comprehensive nutritional support. |
| Sports Nutrition | Beta-alanine is a common ingredient in many sports nutrition products and is used to enhance athletic performance, enhance muscle strength and endurance, and promote muscle recovery after exercise. |
| Dietary Supplements/Nutraceuticals | As an important amino acid, beta-alanine is often added to dietary supplements to supplement nutrients that may be lacking in the daily diet and to support healthy body functions. |
| Skin Lightening | By inhibiting the enzyme responsible for melanin production, beta-arbutin effectively reduces the appearance of dark spots, hyperpigmentation, and uneven skin tone. |
| Hyperpigmentation Treatment | Beta-arbutin's ability to eliminate pigmentation without disrupting the skin's delicate balance makes it a popular ingredient in skin care formulas. |
| Anti-Aging Products | The antioxidant power of beta-arbutin protects the skin from the damage of time. By neutralizing free radicals and fighting oxidative stress, it helps protect skin from environmental aggressors and premature aging. |
| Dermatology | Beta-arbutin is recommended for the treatment of several hyperpigmentation disorders. Whether it’s melasma, post-inflammatory hyperpigmentation, or age spots, the efficacy and safety of beta-arbutin have made it a cornerstone of dermatology practice. |
Arbutin, an active ingredient widely utilized in the cosmetic industry, has garnered significant attention for its remarkable skin whitening properties. However, recent research has shed light on an additional facet of arbutin—the potential anticarcinogenic effects it can offer.
The case examined the impact of β-arbutin on MCF-7 cells and identified the key mediators of its anticarcinogenic effects. It was observed that when MCF-7 cells were exposed to the LD50 dose of β-arbutin, inflammation and genotoxicity were stimulated. Surprisingly, there were no significant changes in oxidative stress, endoplasmic reticulum stress, or proliferation levels. These findings led to a remarkable discovery: β-arbutin triggers the activation of p53 and cas3 pathways through inflammation and genotoxicity, ultimately inducing apoptosis in the cells. This groundbreaking revelation paves the way for the potential use of β-arbutin as an anticancer agent. The determination of these mechanisms not only highlights the anticancer potential of β-arbutin but also opens up new perspectives and possibilities for innovative treatment approaches.
Mechanisms that mediate the anticarcinogenic effects of β-arbutin administration to MCF-7 cells (Omer Hazman, et al., 2021)